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Preparations of drugs: Mr injection of 1 mg / ml to 10 ml (10 mg) or 50 ml (50 mg) vial. Dosing and Administration of drugs: monotherapy in adults and children: 50 - 100 mg/m2 as a single i / v infusion for 6 - 8 hours every 3 - 4 weeks or slow i / v infusion of 15 - 20 mg/m2 daily for 5 days every 3 - 4 weeks, the dose decreases with oppression function of bone marrow to reduce the risk of bacterial Drugs of Abuse is recommended to dilute immediately before use (infusion should be completed within 24 hours after cooking district) combination therapy: Testicular cancer: vinblastyn, bleomitsyn; for the treatment of ovarian cancer: cyclophosphamide, doxorubicin, heksametylmelamin, ftoruratsil; to treat head and neck cancer: bleomitsyn and methotrexate; repeated courses should not start until the level of serum creatinine were reduced to 140 mmol / l and / or plasma levels of urea - to 9 mmol / l, the number of formed element circulating blood does not reach the accepted level (platelets? 100h109 / l, leucocytes? 4h109 / l should be removed to control basal audiohramu deafness; to input necessary hydration - / v infusion of 2 L Mr 5% glucose fizr-no (1 / 2 - 1 / 3) for 2 - 4 h; entering cisplatin for others. Platinum compounds. Dosing and drug Slow Release 400 mg/m2 as a / v infusion duration of input - from 15 minutes to 1 hour following a course of therapy prescribed no earlier than 4 weeks, with increased risk Irritable Male Syndrome depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. Side effects and complications in the use of drugs: the maximum inhibition of blood (thrombocytopenia, neutropenia, leukopenia) were in the 21-day chemotherapy in adsorptive 28-day resumed, with impaired renal function suppression of hematopoiesis is usually difficult, vomiting (sometimes drastic ), nausea, which usually terminated after 24 h adsorptive treatment, abdominal pain, diarrhea, constipation, functional deviations from normal liver tests (ALT and total bilirubin and alkaline phosphatase), peripheral neuropathy, paresthesia weaknesses, potential cumulative neurotoxicity, rarely adsorptive ototoksychnist and other sensory disorders such as blurred vision and changes in taste, violation of adsorptive functional tests, electrolyte balance - decline; azoospermiya and amenorrhea, AR (rash, itching, and occasionally - bronchospasm), injection site pain, asthenia, alopecia, gemmological uremic s-m. Number 1; concentrate for the preparation of Mr infusion, 10 mg / ml to 5 ml (50 mg) or 15 ml (150 mg) or 45 ml (450 mg) vial. Side effects and complications in the use of drugs: severe nausea and vomiting usually begin within 1 - 4 pm. Pharmacotherapeutic group: L01XA02 - Antineoplastic agents. Preparations of drugs: powder for Mr injection of 2 mg vial. after treatment and adsorptive last up to one week; nephrotoxicity, cumulative dose-related and may limit the application, with repeated treatment renal failure becomes longer and harder, as with light miyelotoksychnist Lake, and with thrombocytopenia, and adsorptive - with anemia, anaphylactoid reaction (swelling of the face, dizziness, tachycardia, hypotension and skin rash), reaction developing within a few minutes after administration of cisplatin and disappear after the / in the introduction of adrenaline, corticosteroids and / or antihistamines, in 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); adsorptive рівні сечової кислоти відзначаються" onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and / or tetany), hyperuricemia (at doses> 50 mg/m2), peak uric acid levels observed in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, loss of vibration sensitivity), blurred vision and color perception may develop neuritis of the optic nerve. Contraindications to the use of drugs: hypersensitivity to the drug, severe suppression of bone functions hematopoiesis, recent significant blood loss, pregnancy, lactation, severe liver and kidney.